Cheminformatics Workshop on 6 jan,2013

One day Workshop from BII Noidahttp://bii.in/chem/Cheminformatics.html

Seminar on Pharma Regulation & Lifescience

 

This is to inform all the aspirants that Bioinformatics Institute of india, Noida is organising a seminar on Pharma "Regulation & Life science" in February 2013.

There will be a poster presentation also. Other Details regarding seminar will announced shortly.

Please keep a watch on this space.

For Registration kingly contact:

BIOINFORMATICS INSTITUTE OF INDIA

C-56A/28, Sector - 62,

Noida - 201 301 (U.P) (INDIA)

Call : 0120-4320801/02

Mobile : 09818473366,09810535368

E-mail : info@bii.in 

 website: www.bii.in

 

 

 

 

 

 

Wish you a joyous Navratri and a Happy Dussehra

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Bioinformatics Institute of India

Bioinformatics from aartisoni12

Pharma Regulatory Affairs Course

Pharma Regulatory Affairs from aartisoni12

Bioinformatics Institute of India

Bioinformatics Institute of India (BII), set-up in the year 2002 has acquired international reputation by conducting industry oriented knowledge enhancement programs in the emerging domains of life science. BII was established by the prestigious Confrere Educational Society. Within a short span of a decade, BII has traversed many milestones in academic excellence and is today recognized as premier institute for providing the training in the area of Bioinformatics, Biotechnology, Pharma, Clinical Trials etc. The course-curriculum has been designed on global industrial pattern to fill the gap between academia and industry has lead BII to attain professional expertise in the field of life science and its allied area.

Quality Policy


Notice:
BII is determined to maintain its reputation as an authority which will not tolerate any kind of fraud. We have no branches & no sister concerns. Some people are misleading the students in the name of BII. Students are warned to be aware of duplicacy / piracy of certificates and course materials offered in the name of BII by any individual organisation other than our corporate office

BII Quality policy is as per ISO certification number NS-EN ISO 9001:2008 requirements which have been developed and implemented according to quality management system to demonstrate its ability to consistently provide education and training in the life sciences and pharma domain. Our quality management system complies with the requirements of the ISO and meets the end-user statutory and regulatory requirements through the effective application of the educational systems as per vision and mission of the institute. BII establishes documents, implements and maintains the quality management system and continually improves its effectiveness in accordance with the requirements of ISO:9001:2008.

BIOINFORMATICS INSTITUTE OF INDIA

C-56A/28, Sector - 62,
Noida - 201 301 (U.P) (INDIA)
Call : 0120-4320801/02
Mobile : 09818473366,09810535368
E-mail : info@bii.in
www.bii.in

Admission open in University Programs of Jamia Humdard

Bioinformatics Institute of India (BII), offers University Programs of Jamia Hamdard (3304) :
Jamia Hamdard Programs (3304)

•Post Graduate Diploma in Bioinformatics(PGDB)

•Post Graduate Diploma in Chem Informatics(PGDC)

•Post Graduate Diploma In Pharmaceutical regulatory Affairs (PGDPRA)

Course Duration:
•Minimum one year.
•Maximum two year.

Medium of Instruction: English

Program Eligibility
A candidate seeking admission to the above programme must passed B.Sc. examination in Biology or B.Sc. in Maths/Statistics with Biology as one of the subjects in 10+2 examination, from a recognized institution. No age bar.

Admission Procedure


•Submission of Application
•Enclosures:
For More Detail Contact:

BIOINFORMATICS INSTITUTE OF INDIA

C-56A/28, Sector - 62,
Noida - 201 301 (U.P) (INDIA)
Call : 0120-4320801/02
Mobile : 09818473366,09810535368
E-mail : info@bii.in
Website : http://bii.in/programs/regularPrograms/jamia_hamdard_programs.html#

Cheminformatics: An Emerging Computational tool

In the life path of researchers who emphasize to generate as much data as possible and then race into the next project, the next data set, the next batch of compounds to screen, and the next big drug candidate to send through clinical trials and ultimately, hopefully, to market. Chemoinformatics is rapidly becoming a core part of drug designing. The article features the academic and commercial educational programs that are available in chemoinformatics. Lets start the new journey of computational chemistry:

Field details:

It is the fusion of IT and Chemistry. This new branch is called “Chemin-formatics”. In Cheminformatics chemical information is stored, managed and chemical problems are solved with the help of Information Technology.

 The field that studies all the aspects of the representation and use of chemical and related biological information on computers i.e design, creation, organization, management, retrieval, analysis,  dissemination, visualization and use of chemical information.

Concepts and techniques: Molecular similarity, Quantitative-structure Activity Relationship(QSAR), Substructure Search, Molecular Depiction, 3D structure generation. These are Combinatorial Chemistry and High Throughput Screening (HTS).

“Cheminformatics exploits systems chemical biology to find pathways involved in adverse drug reactions. The second one was visualization of compound on ADME landscape. The internship programs in some pharmaceutical companies not only provided the opportunity to learn the whole process of drug discovery, but also allowed to study the hot research topic in the industry.

Cheminformatics is highly related to some other areas:

·      Computational Chemistry: the application of mathematical and computational methods  particularly to theoretical chemistry.

·      Molecular Modeling: using 3D graphics and optimization techniques to help understand the nature and action of compounds and proteins.

·      Computer-Aided Drug Design: the discipline of using computational techniques to assist in the discovery and design of drugs.

·      Chemogenomics - the study of relationships between chemical compounds and genes.

·      Cheminformatics has some traditional areas of application (pharmaceutical drug discovery, databases of available chemicals, journal article indexing, patent databases) and some newer ones (pathway databases, probe discovery, polypharmacology, toxicology, etc). In particular, there has recently been a big increase in the amount of chemical information in the public domain, and a deeper integration with other related areas.

Future porspects:

Cheminformatics has wide applications in drug discovery. Many companies offer Data management in cheminformatics. However, there is still a lot of variety, and almost every lab will need to turn to more than one provider for their chemical information needs. Open source software, beloved of academics for decades, is now beginning to penetrate the pharmaceutical industry.

Bio-Rad, a company best known for research and development in electrophoresis, officially became the Informatics Division in 2001. That year also saw the first release of BioRad’s premier chemical data management program. This program provides tools for storing and searching chemical ‘meta-data’ from infrared and NMR spectroscopy and mass spectrometry, as well as structures and other chemical information.

Hungarian cheminformatics company Chem-Axon, founded in 1998, is quite a new entrant to the field. Its first product, a chemical structure and reaction editor, Marvin, was released two years later, and a database management tool, JChem Base, developed to go with it.

Cheminformatics is to enable scientists to design and run their own complete drug discovery projects in a seamless electronic environment and to test drugs targeting the central nervous system and preclinical safety testing. The cheminformatics software industry is a relatively small one, and, increasingly, many vendors look to collaborate on particular projects rather than compete.

In the near future,  there is booming scope for the students who have studied Cheminformatics will be required not only in India but in foreign countries too.

Educational institutions:

The Indian institutes which offer training programs / diploma courses include :

1. Malabar Christian College, Kozikode. (1 Year P.G. Diploma in Cheminformatics, Eligibility for the course is M.Sc. (Chemistry) / M.Sc. (Bio – informatics) / M.Pharma)

2. Institute of Cheminformatics Studies, Noida.

3. Department of Chemistry, Jamia Hamdard Deemed University, New Delhi.

In USA and in Britain several universities have started M.Sc. courses in cheminformatics. Some of these are :

1. Johns Hopkins University, School of Medicine

2. University of Manchester – www.manchester.ac.uk.

3. University of Sheffield – www.shef.ac.

4. University of Indiana – www.informatics.indiana.edu.

Apart from the above, Bioinformatics Institute of India(www.bii.in), situated in Noida, U.P, India is a pioneering Institute of Life Sciences(distance learning and short term programmes), which is providing opportunities to the students, professionals to develop an expertise in the field of Bioinformatics. BII guide and train the students in the field of cheminformatics and its various aspects regarding drug designing such as virtual  screening, combinatorial library generation, pharmacophore and QSAR analysis with some specialized tools and softwares.

ELIGIBILITY:

B.Sc/ M.Sc/ M.Phil/ MS/ Ph.D Bioinformatics/ Microbiology/ Biochemistry/ Biotechnology/ Agriculture/ Food Technology/ Organic Chemistry/ Botany/ Zoology/ Statistics/ Life Sciences and other Divisions of Life Sciences like B.VSc, BAMS, BHMS, MBBS/ BDS/ B.Pharm/ M.Pharm/ B.E/ B.Tech / M.E/ M.Tech.

Job Opportunities:

The aim of this field is to cultivate researchers and scholars in chemistry and associated disciplines with knowledge and skills appropriate for career as cheminformatics specialists in the Pharma industry and related industries. Even provides comprehensive understanding of this fast growing field in science and technology starting from basic principles to the point of application in various fields of chemistry, biotechnology, drug development and drug designing. Cheminformatics helps to increase researchers efficiency for designing better drugs faster. Chemical, Agrochemical, Biotechnology and Pharmaceutical companies are in great need of students with extensive knowledge of chemistry and computer science, that is, cheminformatics.

Bashah Javed

Faculty of Bioinformatics

Bioinformatics Institute of India.

Noida.

E-mail: bashah@bii.in

Clinical Trial of a Cancer patient

I am writing a little bit about Clinical trials on cancer patients. These trials are performed to figure out the best way to treat cancer. In the early phase of clinical trials, patients that are diagnosed with cancer have to sign a treaty that they are participating in the clinical trial to help with their pain. The pain from the cancer is severe. Patient will be told about the medication , the side effects , and the potential benefits. Then patient will sign the consent form. In this trial they have to  keep a diary on how much pain is controlled  and how much different doses of the medicine took. The patient will receive a box of pain meds and it will contains pills of different strengths. Then 30 minutes, 60 minutes, 90 minutes after medication  the pain level  has to be note down each time. If the pain improves and is well controlled then the dose have to be taken when it is needed. If this doen’t work then an increased dose has to be given next time. This will figure out the best way to treat cancer pain. In first phase of pain medication trial a very low dose will be given which will show effect or not, depends. Now to get relief from pain the dose has to be increased may be four times and that gives a relief from pain but with sleep. So controlling  most of the pain that has to be done with lowering the dose and without falling asleep. If the pain for the cancer become worse so the highest dose can also be given.

Bashah Javed

Faculty of Bioinformatics

BII, Noida.

Novartis wants U.K. to quash off-label Avastin use

Novartis is taking up arms against British eye doctors who use Roche's Avastin. Novartis markets Lucentis, a much pricier treatment for wet age-related macular degeneration. Lucentis is licensed for that use. It's recommended for that use by the U.K.'s cost-effectiveness gatekeepers. Avastin is not.

Some local National Health Service operations are repackaging Avastin, a cancer drug that's actually related to Lucentis, into syringes for eye use. While quite expensive as a cancer treatment, at such tiny doses, Avastin costs a tiny fraction of Lucentis' price. Novartis is asking a U.K. court to review NHS reimbursements for off-label Avastin treatment.

The U.K. debate mirrors another in the U.S., where repackaged Avastin has been broadly used by eye doctors. Recent head-to-head study data suggested that Avastin was as effective at treating wet AMD as Lucentis, but the cheaper drug presented a higher risk of side effects. The off-label Avastin use also got some negative publicity last year after several clusters of eye infections, some of which led to vision loss, were linked to the drug.

Novartis is using Avastin's side-effects risks to bolster its case for Lucentis. "It is unacceptable to put the safety of patients at risk through the widespread use of an unlicensed treatment when a licensed medicine is available," Novartis said in a statement. "It undermines the regulatory process that was introduced to safeguard patients."

The local NHS operations, however, say that Avastin is safe, the BBC reports. "Avastin is internationally recognized as an effective treatment for AMD, and, for example, over 50% of AMD patients in the United States are treated with Avastin," officials said.

With its top-seller Diovan facing generic competition, Novartis is leaning on newer products such as Lucentis to take up the slack. As Reuters points out, the eye drug's sales jumped by 30% in the first quarter, to $567 million.

Yash shrivastava

Marketing Executive

BII

A Successful Presentation of BII for Research collaboration with Dr.K.N.Modi institute

A big day just passed for BII, but had left its impressions; 4-MAY-2012 was very special to everyone in BII, what was so special in it? Specialty was the Research collaboration proposal between two institutes. Now not making you wait I will tell you we have got very special guests in our premises, Dr. K.N.Modi Institute of Pharmaceuticals Education & Research represented by their faculties & students have come for a visit.

Guests have arrived at 1200 Hrs, we welcomed them with open arms. As it was a sunny day, we arranged refreshments before the commencement of any proceedings of the day. Round 1230 Hrs. our COO Mr. Anshul Gupta & Technical Head Mr. Ranjan Kumar expressed the warm welcome on the behalf of BII.  Now we took off for the technical part of the day; first we had “Cheminformatics session” took by our Bioinformatics faculty Mr. Bashah Javed which last for one hour. The guests were taking every bit of information from the presentation. After it, we moved to the Lunch break for all our guests and students.

Post lunch was even more exciting for all, as it had got demonstrations in it. We divided the students from Dr. KN. Modi into two batches. First batch took the demonstration of Drug Designing & analyzing software V-Life on the other hand second batch was on an exciting ride of instrumentation in the Biotech Lab with Ms Aditi Banerji. Then we swapped the batches for the demonstrations. Meanwhile our Guests faculties were with our Management in Directors’ Chamber on the academics discussions and interestingly on the research collaboration which will take place.

After the insightful technical sessions we all assembled at one place and our Honorable CEO Mr. Shivendra Misra thanked our guests for their eminent presence. And then our Honorable guest Mr. Vijay Sharma (HOD-Pharm. Chem.) expressed his views on the day, then we call for the day.

I would like to express my gratitude to the Director, members of BII, ICIS and our marketing team member Ms. Ritu Pal and Mr. Yash Srivastava for such a wonderful arrangements and presentation of BIII would also like to give special thanks to Ms Aditi Banerji for live demonstration of molecular biology experiments in front of faculty and students and last but not the least for such a tremendous and extra ordinary work of our junior division staff which are essential part of our organization thank you for bringing us at a successful commencement of the day.

 Author

Gourav Kumar

Faculty cum Research Associate

Biotechnology BII

Biotechnology in Pharmacology

Starting with the last paragraph where we have finished with DNA structure Now it’s obvious that DNA looks a very attractive molecule for life processes. Thanks to Henri Becquerel discoverer of radioactivity, Its gives a perfect way to Alfred Day Hershey and Martha Cowles Chase to prove DNA on protein as a genetic material. DNA Which have ability to move forward for Transcription process which finally lead to synthesis of new polypeptide chain (a unit of protein) with process known as translation.
Proteins are considered as body building material, and as all enzymes are protein, it makes proteins very essential for metabolic activities. So discovery of DNA as a genetic material reveals the secrets of life i.e. how conservation of species and their phenotypic character is possible.

Factors required for transcription

A. Prokaryotic

1. RNA polymerase (enzyme that catalyzes the synthesis of RNA from a DNA template).

a) Core enzyme = 3 different types of subunits (2a; 1b; 1b’)

(1) b - binds incoming nucleotides
(2) b’ – binds DNA
(3) a - helps with enzyme assembly; interacts with other transcriptional activator proteins; recent work demonstrated that a also interacts with some DNA sequences

b) Holoenzyme = core + s factor (recognizes the promoter)

c) s factors – Initially, people thought that there was only one s factor that functioned to direct RNAP to the promoters of genes. Later, different classes of s factors were found. Each s factor directs RNAP to a different type of promoter (differentiated by a specific DNA sequence in the promoter).



2. Accessory transcription activator proteins
a) IT have ability to bind with specific DNA sequences and help RNA polymerase to initiate transcription via protein-protein interactions or by altering the structure of the DNA.

b) Transcription of some promoters requires an accessory transcriptional activator; at other promoters, the activators just increase the rate of transcription but are not absolutely required.

3. Template DNA containing gene or genes to be transcribed

4. Promoter - The regulatory element that determine when a gene “turned on” (transcribed) or “turned off”. The promoter DNA is located upstream of the gene and contains a sequence which is factor of RNAP and other transcription factors bind. Different classes of promoters have different DNA sequences. Deviations from the consensus sequence decrease the level of transcription.

5. Weak promoters (ones that have poor sigma recognition sequences) have additional sequences to which transcriptional activators can bind.

6. NTPs, Mg2





Gourav KumarFaculty cum Research associate
Bioinformatics Institute of India

Cheminformatics: An Emerging Field

Cheminformatics is an emerging field that uses information technology to a range of problems in the field of chemistry as well as drug discovery. Cheminformatics is a fast growing field and there is a lack of qualified scientific professionals who can use computers and databases for chemical compounds or drug development. Basically it is the application of information technology to chemistry. The efficient search of such stored information includes topics that are dealt with in computer science as data mining, information retrieval, information extraction and machine learning. The applications are the Chemical data collection, analysis and management, chemical data representation, database design, chemical structure prediction, compound library, database mining, QSAR/ QSPR, Statistical models and descriptors. The various aspects are the Information Acquisition i.e. methods for collecting data from the source or from various theories, Information Management i.e. storage and retrieval and Information use i.e. analysis, correlation and application to problem. The methods that included are force fields, molecular dynamics, QSAR, molecular docking and pharmacophore. The software that used are Amber (use for protein and DNA), OPLS (Optimized Potentials for Liquid Simulations), Charmm (C-22 for protein and C-27 for DNA, RNA, and Protein). These in silico techniques are used in pharmaceutical companies in the process of drug discovery. These methods can realize its immense potential, the chemical and pharmaceutical industries are now going in for qualified and trained staff in cheminformatics. New career avenues have also opened up for IT as well as computer-proficient science graduates for acquiring, managing, or utilizing chemical information with the help of computer software. The aim of Cheminformatics is to provide comprehensive understanding of this fast growing field in science and technology starting from basic principles to the point of application in various fields of chemistry, biotechnology, drug development and drug designing.

Author: Bashah Javed

Faculty Bioinformatics,

BII.

Parkinson’s disease|Bioinformatics Institute in Noida

Parkinson’s disease is a neurological illness named after Dr. James Parkinson, a physician who was the first to describe in his essay “An essay on the Shaking palsy” 1817. Parkinson‘s disease is a disorder caused by the gradual loss of cells in a small part of the brain called the substantial nigra. The loss (death) of these cells produces a reduction in a vital chemical called “dopamine”, which causes symptoms that may include loss of facial expression, reduction in speech volume and clarity, change in size of handwriting, dry skin, constipation, urinary difficulties and depression. It is a progressive disorder; hence these symptoms worsen with time. Parkinson’s disease belongs to a group of conditions called movement disorders. It is characterized by muscle rigidity, tremor, a slowing of physical movement (Bradykinesia) and in extreme cases, a loss of physical movement (Akinesia). The primary symptoms are the results of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problem. Most people with Parkinson’s disease are described as having idiopathic Parkinson’s disease (having no specific cause). There are far less common causes of Parkinson’s disease including genetic, toxins, head trauma, cerebral anoxia, and drug- induced Parkinson’s disease. In recent year, a number of specific genetic mutations causing Parkinson’s disease have been discovered, including in certain population (Contursi, Italy). These account for a small minority of cases of Parkinson’s disease. Someone who has Parkinson’s disease is more likely to have relatives that also have Parkinson’s disease. However, this does not mean that the disorder has been passed on genetically. There is also recent evidence that a common gene defect contributes susceptibility to both Parkinson’ disease and Alzheimer’s disease.

Author Name Mr. Ranjan Kumar

HOD, Bioinformatics Institute of India

INDIAN PHARMACEUTICAL MARKET- REVIEW

Today I feel enthusiastic while writing this article as Pharmaceutical market is a big ocean; and I had tried my best to hold few drops on Indian economical face.

The Indian pharmaceutical market is highly competitive and remains dominated by low-priced, domestically-produced generics. Despite having the second largest population in the world and a growing middle class with high healthcare expectations, India accounts for less than 2% of the world pharmaceutical market in value terms. In one of the world's better performing economies, spending on pharmaceuticals accounts for less than 1% of GDP and average per capita spending remains one of the lowest levels in the region.

India’s biopharmaceutical sector is currently experiencing double digit growth and this is expected to continue, driven by the vaccines market. Growth drivers include education and increased awareness of disease prevention, increases in disposable income and government participation in immunization programmes. Continued growth is also expected in the diagnostic and therapeutic segments, including cancer and diabetes.

The Indian Pharma industry is responsible for around 10% of world pharmaceutical production. Over the last few years, a number of Indian pharmaceutical companies have been targeted for foreign acquisition. Concerns have been raised that this trend could adversely affect generic drug prices in India. The need to maintain low prices for essential medicines has been addressed in the government’s draft National Pharmaceutical Pricing Policy (NPPP), released in 2011. The proposed NPPP focuses on the National List of Essential Medicines (NLEM), which is periodically revised. The headline major change is a move from the principle of cost-based pricing to a market-based pricing model. The Department of Pharmaceuticals argues that market-based pricing would result in more transparent and fair pricing, as well as increasing competition in the marketplace. Price regulation will encompass all drugs listed in the NLEM, as well as formulations containing combinations of drugs listed in the NLEM; this will include combinations comprising listed drugs and unlisted drugs. If the NPPP is implemented, around 60% of the drugs currently available in India will come under price control.

Ritu Pal

BII

BII offers short term courses:-

· Professional Designation in Clinical Trials Data Management

· Professional Designation in Medical and Scientific Writing

· Professional Designation in Clinical Trials

· Professional Designation in Computational Biology

· Professional Designation in Intellectual Property Rights and Patents

Call us now :-

0120-4320801/802

9810535368, 9818473366

Biotechnology in Pharmacology|9810535368

Finding a chance to write on the blog of BII is a subject of honor for me. I am just trying to make reader familiar with the world of Biotechnology/life sciences and there relation with Pharmacology, Here I am trying to set some epic of DNA which is most fascinating thing in health care system as per my view. After the discovery of nuclein (nucleic acid) by Johannes Friedrich Miescher in 1869 which is one of most remarkable work in the world of Life Sciences. It initiate a new era in Life sciences especially in molecular biology. In the initial of 20^th century when protein is regarded as the most complex structure as well as genetic material, DNA comes as a medicine. Structure of DNA reveals how the characters are transferred from parents to offspring and transcript the information from genotype to phenotype via RNA and Protein. Writing anything is looks less as per broad view of DNA but 5’ to 3’ end always attract me so I will try my level best to sum-up maximum stuff about DNA and its relation with pharmaceutical industry in my this and upcoming next blogs.

Structure of DNA is very important because it is the key role for remedy of viral, bacterial and mutational problems. As its chemical structure elaborate with addition of pentose sugar purine, pyrimidine and tri phosphate molecule. Where sugar molecule deoxygenate at 2’ no of carbon while Nitrogenous bases are at 1’, when we talk about phosphate structure its added at 5’.That whole compound is regarded as nucleotide, and every new nucleotide join at 3’ end and constitute a new DNA.

Source: Mr. Gourav Kumar

Faculty:Bioinformatics Institute of India